BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab06312(PER2 antibody) at dilution of 1:600
IP Result of anti-PER2 (IP:FNab06312, 3ug; Detection:FNab06312 1:300) with HEK-293 cells lysate 1000ug.
Background
PER2, also named as KIAA0347, is a component of the circadian clock mechanism which is essential for generating circadian rhythms. PER2 is a negative element in the circadian transcriptional loop. PER2 influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. It negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) which is characterized by very early sleep onset and offset.